Antifungal Piperolides from Piper malacophyllum (Prels) C. DC
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چکیده
O estudo fitoquímico biomonitorado do extrato em CH 2 Cl 2 das folhas de Piper malacophyllum através da técnica de bioautografia frente a fungos, resultou no isolamento de dois piperolidos bioativos: 4,6-dimetóxi-5-E-fenilbutenolido (1) e 4,6-dimetóxi-5-Z-fenilbutenolido (2). Essas substâncias foram identificadas com base na análise dos espectros de IV, EM e RMN, incluindo técnicas bidimensionais, e comparação com dados descritos na literatura. A configuração E da ligação dupla confere maior atividade para 1 considerando-se que as quantidades mínimas de 1 e 2 necessária para inibir o crescimento dos fungos Cladosporium cladosporioides e C. sphaerospermum foram de 1,0/1,0 μg (1) e de 5,0/10,0 μg (2), respectivamente.
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تاریخ انتشار 2005